Date: 2/24/25

Version Affected: Lasergene 18.0

Version Fixed: N/A

Issue: Attempting to launch SeqBuilder Pro or Protean 3D when McAfee antivirus software is running on the same machine results in the error message: “<Application Name> Fatal Error. Couldn’t find a valid data manager executable. C:\Program Files (x86)\DNASTAR\Lasergene 18\<filename>.” The only option is to press OK, which causes the SeqBuilder Pro or Protean 3D to close.

This occurs when McAfee antivirus unnecessarily quarantines either or both of the Lasergene files: DM18.exe and DMI.cfg. Simply going to your McAfee quarantine folder and restoring the files manually (as in the image below) does not work, as McAfee will quarantine the files again the next time you attempt to launch SeqBuilder Pro or Protean 3D.

Resolution: To resolve this issue, you may do either of the following:

• Remove or disable McAfee antivirus software on the machine where you want to use SeqBuilder Pro or Protean 3D.

• Contact McAfee support directly and request that any items from any DNASTAR or Lasergene folders be whitelisted for your account.