Lasergene 17.6 Release Notes

LASERGENE 17.6 RELEASE NOTES

Lasergene 17.6 is now available to download.

This release includes:

Significant usability improvements for protein analysis in Protean 3D
New NovaFold AI-Multimer workflow using AlphaFold-Multimer method
Powerful new functionality for sequence alignments and phylogenetic analysis in MegAlign Pro
Updates for RNA-Seq and templated genome alignments in Lasergene Genomics
Bug fixes for SeqBuilder Pro and SeqMan Ultra

Updates for sequence alignments in MegAlign Pro include:

A new gene homology alignment algorithm enables users to identify and compare subsets of homologous genes in bacterial genomes or eukaryotic chromosomes with ease
RAxML-NG is now available for fast and accurate Maximum Likelihood phylogenetic inference and bootstrapping calculations
Gap editing allows adding, removing, and shuffling gaps in the alignment
Translate nucleic sequences or subsequences into a protein alignment, with a single click
Use a translation track to guide sequence trimming before an alignment, or for gap editing afterward

Improvements for protein analysis in Protean 3D include:

Updated rendering engine that allows Protean 3D to run natively on macOS and provides more photo-realistic images
New NovaFold AI-Multimer workflow for predicting the structure of multimeric assemblies using the AlphaFold-Multimer method
WYSIWYG (What-You-See-Is-What-You-Get) selection in the Structure view enables precise selection directly on the structure
Custom label creation for atoms, residues, and other structural components
The ability to export 3D models for use in other applications

Updates for NGS workflows in Lasergene Genomics include:

Auto-generation of PCA plots and Volcano plots for differential gene expression using EdgeR or DESeq2 for RNA-Seq alignments.
Updated human genome template packages for whole exome/genome sequencing and variant analysis
Several bug fixes in SeqMan Ultra