Antigenicity – Welling

The Welling track predicts antigenicity using the method of Welling et al., 1985. Previous methods assumed that antigenic regions were mainly hydrophilic regions on the surface of a protein. By contrast, the Welling method is based on the percentage of each amino acid present in known antigenic determinants compared to the percentage of the amino acids in the average composition of a protein.

To apply this track to the sequence:

In the Tracks panel, expand Immunogenicity, then Antigenicity, and check the box next to Welling. The track will now be visible in the Sequences view.

To edit track options:

Select the track in the Tracks panel. Open the Track Options section, which appears as follows:

• Residues to average – number of residues to be averaged when constructing each point in the plot. The default is 9.

Click if you wish to return to the default value.