LASERGENE 19.0 RELEASE NOTES
Lasergene 19.0 brings major advancements across protein, genomics, and transcriptomics workflows. New algorithms and protein design force fields, integrated annotation tools, integration with the SciNote ELN, expanded cloud and local modeling support, and enhanced workflow accessibility empower you to analyze data faster, collaborate more effectively, and accelerate discovery.
👉 Download Lasergene now to start using the latest features.
Protein Structure & Interactions
Protean 3D introduces new flexibility for structure prediction and protein design.
- Set up Boltz, AlphaFold-Multimer, NovaDock, and NovaFold Antibody predictions through a unified structure prediction wizard in Protean 3D
- Cloud-based protein modeling predictions are included with each Lasergene Protein license, and can be used for any type of modeling prediction. Additional predictions can be purchased as needed
- Run Boltz, NovaDock, and NovaFold Antibody predictions locally for enhanced data security and unrestricted usage
- Use the prediction wizard to easily configure multiple structure predictions using a common fixed input and a series of variable protein or ligand binders
- Choose from multiple Amber force fields during protein design
Variant Analysis
Lasergene Genomics delivers faster assembly and expanded workflow compatibility.
- Assemble and analyze data generated on the Element sequencing platform
- Experience optimized SeqMan NGen assembly performance for up to 2× faster processing compared to Lasergene 18.1
- Validate sequence assembly results with automated accuracy testing and comprehensive captured-region performance metrics
Genome Visualization
GenVision Pro introduces new data tracks with gene-finding capabilities. Apply data tracks to the Analysis view to identify the locations of:
- ORFs
- splice sites
- transcription factor binding sites
De Novo Genome Assembly
Unlock enhanced long-read de novo assembly performance in SeqMan NGen.
- Assemble sequences faster and generate longer contigs with an improved alignment algorithm
- Automatically annotate assemblies using AUGUSTUS and Swiss-Prot information
- Streamline workflow setup with simplified assembly parameter selection
Antibody Repertoire Analysis
SeqMan NGen features a new beta transcriptomics workflow for single-cell V(D)J antibody repertoire analysis. This workflow enables the characterization of B-cell clonotypes and allows you to recover paired antibody chain sequences from 10x Genomics immune profiling data.
- Analyze single-cell BCR immune profiling FASTQ data from human and mouse 10x Genomics experiments
- Recover paired heavy and light chain antibody sequences using barcode-aware de novo assembly and integrated local IGBlast annotation
- Identify clonotypes, evaluate sequence productivity, and predict antibody structures and antigen binding using the Boltz and NovaFold Antibody algorithms in Protean 3D
SciNote Electronic Lab Notebook (ELN) Integration
SeqBuilder Pro now integrates with the SciNote electronic lab notebook (ELN), helping your lab improve data organization, collaboration, traceability, and regulatory compliance.
- Connect SeqBuilder Pro with any paid tier of the SciNote ELN
- Save and manage SeqBuilder Pro sequences, projects, images, primer designs, and virtual cloning workflows to SciNote
- Improve data traceability and collaboration with SciNote features including electronic signatures, audit trails, automated reporting, and FDA 21 CFR Part 11 compliance
Additional Enhancements
Lasergene 19.0 includes a range of new usability and accessibility features across multiple applications and packages:
- Automatically annotate a FASTA file with AUGUSTUS and Swiss-Prot data using the DNASTAR Navigator
- Identify a microbial strain using PubMLST from the DNASTAR Navigator
- Choose TPM (Transcripts Per Kilobase Million) normalization as an option for RNA-Seq assemblies in SeqMan NGen
- Hear nucleotide and amino acid residues spoken aloud while entering sequences manually or configuring BLAST search queries (multiple Lasergene applications)
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